For patients with severe depression that has been unresponsive to medications and/or electroconvulsive therapy, Ketamine infusions are offering great promise Ketamine is a general anesthetic agent that has been used by anesthesiologists for 50 years For the past decade it has been studied for the treatment of refractory depression is sub-anesthetic doses Ie, in small intravenous doses over a period of one hour that do not result in a loss of consciousness It can be effective in treating all forms of severe depression including post-partum and bi-polar depression Because there is no loss of consciousness, treatments can be safely performed in our private office setting in downtown Manhattan